پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 25 |
| تعداد شماره‌ها | 955 |
| تعداد مقالات | 7,830 |
| تعداد مشاهده مقاله | 13,187,540 |
| تعداد دریافت فایل اصل مقاله | 9,324,791 |
بررسی اثرات افزودن همزمان آلفا توکوفرول (ویتامین E) و کربن نانوتیوب‌های چند دیواره عامل دار (MWCNT) بر خواص مکانیکی و زیست سازگاری ماتریس پلیمری پلی‌اتیلن با وزن مولکولی بسیار بالا (UHMWPE) باهدف کاربرد در تعویض مفاصل | ||
| زیست شناسی کاربردی | ||
| مقاله 6، دوره 36، شماره 2 - شماره پیاپی 76، شهریور 1402، صفحه 95-112 اصل مقاله (1.56 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22051/jab.2023.42305.1529 | ||
| نویسندگان | ||
| محسن فکوری1؛ محمد تقی خراسانی* 2؛ مهدی کمالی دولت آبادی3 | ||
| 11-دانشجوی دکتری، گروه بیومتریال، پژوهشکده فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، مشکین‌دشت، کرج، ایران 2-گروه مهندسی پزشکی (بیومتریال)، دانشکده فنی مهندسی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران | ||
| 2دانشیار، گروه پلیمرهای زیست‌سازگار و پلیمرهای طبیعی، پژوهشکده علوم پلیمر، پژوهشگاه پلیمر و پتروشیمی ایران، تهران، ایران | ||
| 3استادیار، گروه مهندسی نساجی، دانشکده فنی مهندسی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران | ||
| چکیده | ||
| مقدمه: پلی‌اتیلن با وزن مولکولی فوق‌العاده بالا (UHMWPE) به علت خواص فیزیکی و شیمیایی فوق‌العاده، طی سه دهه‌ی اخیر به‌عنوان ماده انتخابی در پروتزهای تعویض مفاصل استفاده شده است. بااین‌وجود، سایش و اکسیداسیون این پلیمر در درازمدت منجر به استئولیز (تخریب استخوان) و محدودکردن طول عمر این پروتز می‌شود. یکی از روش‌های موثر جهت جلوگیری از اکسیداسیون، استفاده از α-توکوفرول در ماتریس UHMWPE است. اما حضور این افزودنی به تنهایی باعث بهبود عملکرد مکانیکی UHMWPE نمی شود. از طرف دیگر استفاده از نانوتیوب‌های کربنی چند دیواره (MWCNTs) به دلیل خواص استثنایی مانند مدول الاستیک و نسبت سطح به حجم بالا،نشان داده شده است که می توانند موجب بهبود خواص مکانیکی شوند. با این وجود پیدا کردن مقادیر بهینه استفاده از MWCNTs و ویتامین E به صورت همزمان جهت بهبود خواص مکانیکی این پلیمر بسیار حیاتی و مهم است.روش‌ها: در این پژوهش جهت بررسی و مقایسة تاثیر نانوتیوب‌های کربنی بر خواص کامپوزیت UHMWPE حاوی ویتامین E، دو کامپوزیت، یکی حاوی 0.2 درصد وزنی ویتامین E و دیگری حاوی 0.25 درصد وزنی ویتامین E به همراه 0.5 درصد وزنی MWCNT تولید شدند. نتیجه و بحث: طیف‌سنجی مادون‌قرمز تبدیل فوریه (FTIR) افزایش پیک‌های مشخصه ی کامپوزیت PE-E/CNT را نسبت به کامپوزیت PE-E گزارش داد. گرماسنجی روبشی تفاضلی (DSC) افزایش حدود 7 درصدی بلورینگی را در کامپوزیت PE-E/CNT گزارش داد. آنالیز حرارتی مکانیکی دینامیکی (DMTA) نیز بهبود خواص الاستیک را در کامپوزیت PE-E/CNT نسبت به کامپوزیت حاوی ویتامین E نشان داد. | ||
| کلیدواژه‌ها | ||
| : کامپوزیت UHMWPE/Vitamin E؛ کامپوزیت زمینه UHMWPE؛ کامپوزیت UHMWPE/Vitamin E/MWCNT؛ مفاصل مصنوعی | ||
| عنوان مقاله [English] | ||
| Investigation on the effects of simultaneous adding of α -tocopherol (vitamin E) and Multi-walled carbon nanotubes (MWCNT) on the mechanical properties and biocompatibility of the ultra-high molecular weight polyethylene polymer matrix (UHMWPE) | ||
| نویسندگان [English] | ||
| Mohsen Fackori1؛ Mohammad taghi Khorassani2؛ Mehdi Kamali Dolatabadi3 | ||
| 11.PhD student, Department of Biomaterials, Nanotechnology and Advanced Materials Research Institute, Materials and Energy Research Institute, Meshkindasht, Karaj, Iran 2.Department of Medical Engineering (Biomaterials), Faculty of Engineering, Science and Research Unit, Islamic Azad University, Tehran, Iran | ||
| 2ssociate Professor, Biocompatible Polymers and Natural Polymers Department, Polymer Science Research Institute, Iran Polymer and Petrochemical Research Institute, Tehran, Iran | ||
| 3Assistant Professor, Department of Textile Engineering, Faculty of Engineering, Science and Research Unit, Islamic Azad University, Tehran, Iran | ||
| چکیده [English] | ||
| Introduction: Ultra high molecular weight polyethylene (UHMWPE) has been used as the material of choice in joint replacement prosthesis for the last three decades due to its excellent physical and chemical properties. However, UHMWPE’s wear and oxidation in the long term leads to osteolysis and limits the lifespan of this polymer. One of the effective methods to prevent oxidation is presents of α-tocopherol in UHMWPE matrix. But the presence of this additive alone does not improve the mechanical performance of UHMWPE. On the other hand, the use of multi-walled carbon nanotubes (MWCNTs) has been shown to improve mechanical properties due to their exceptional properties such as elastic modulus and high surface-to-volume ratio. However, finding the optimal concentration of MWCNTs and vitamin E to improve the mechanical properties of this polymer is very vital and important. methods: In this research, to investigate and compare the effects of carbon nanotubes on the properties of UHMWPE/vitamin E composite, two composites were produced, one containing 0.2% by weight of vitamin E and the other containing 0.25% by weight of vitamin E along with 0.5% by weight of MWCNT. Results and Conclusion: Fourier transform infrared spectroscopy (FTIR) reported an increase in the characteristic peaks of PE-E/CNT composite compared to PE-E composite. Differential scanning calorimetry (DSC) reported about 7% increase in crystallinity in PE-E/CNT composite. Dynamic thermos mechanical analysis (DMTA) also showed improved elastic properties in the PE-E/CNT composite compared to the composite containing vitamin E. Finally, | ||
| کلیدواژه‌ها [English] | ||
| Artificial joint replacement, UHMWPE/Vitamin E composite, UHMWPE base composite, UHMWPE/Vitamin E/MWCNT composite | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
Affatato, S., Bracco, P., Costa, L., Villa, T., Quaglini, V. and Toni, A. (2012). In vitro wear performance of standard, crosslinked, and vitamin‐E‐blended UHMWPE. Journal of Biomedical Materials Research Part A, 100:554-560. Aguiar, V.O., Maru, M.M., Soares, I.T., Kapps, V., Almeida, C.M., Perez, G., Archanjo, B.S., Pita, V.J. and Marques, M.D.F.V. (2022). Effect of incorporating multi-walled carbon nanotube and graphene in UHMWPE matrix on the enhancement of thermal and mechanical properties. Journal of Materials Science, 17:1-13. Aliyu, I.K., A, M.K. and Mohammed, A.S. (2021). Wear and corrosion resistance performance of UHMWPE/GNPs nanocomposite coatings on AA2028 Al alloys. Progress in Organic Coatings, 151: 1-10. Amoli, B.M., Ramazani, S.A. and Izadi, H. (2012). Preparation of ultrahigh‐molecular‐weight polyethylene/carbon nanotube nanocomposites with a Ziegler–Natta catalytic system and investigation of their thermal and mechanical properties. Journal of Applied Polymer Science, 125: 453-461. Andjelić, S. and Richard, R.E. (2001). Crystallization behavior of ultrahigh molecular weight polyethylene as a function of in vacuo γ-irradiation. Macromolecules, 34:896–906. American Society for Testing and Materials. (2004). Standard Specification for Ultra-high-molecular Weight Polyethylene Powder and Fabricated Form for Surgical Implants. ASTM International. 13.01: 1-9 Aoki, K. and Saito, N. (2020). Biocompatibility and carcinogenicity of carbon nanotubes as biomaterials. Nanomaterials, 10:264. Bourell, D.L., Watt, T.J., Leigh, D.K. and Fulcher, B. (2014). Performance limitations in polymer laser sintering. Physics Procedia, 56:147-156. Costa, L., Bracco, P., Del Prever, E.B., Luda, M.P. and Trossarelli, L. (2001). Analysis of products diffused into UHMWPE prosthetic components in vivo. Biomaterials, 22: 307-315. Costa, L., Luda, M.P., Trossarelli, L., Del Prever, E.B., Crova, M. and Gallinaro, P. (1998). Oxidation in orthopaedic UHMWPE sterilized by gamma-radiation and ethylene oxide. Biomaterials, 19: 659-668. Davidson, J.A., Schwartz, G., Lynch, G. and Gir, S. (1988). Wear, creep, and frictional heating of femoral implant articulating surfaces and the effect on long-term performance--part II, friction, heating, and torque. Journal of Biomedical Materials Research, 22: 69-91. del Prado, G., Pascual, F.J., Castell, P., Molina-Manso, D., Mahillo, I., Esteban, J. and Puértolas, J.A.(2018).Influence of carbon nanotubes structures embedded in UHMWPE on bacterial adherence. International Journal of Polymeric Materials and Polymeric Biomaterials, 67:934-941. Do Amaral Montanheiro, T.L., Cristóvan, F.H., Machado, J.P.B., Tada, D.B., Durán, N. and Lemes, A.P. (2015). Effect of MWCNT functionalization on thermal and electrical properties of PHBV/MWCNT nanocomposites. Journal of Materials Research, 30: 55-65. Dolezel, B. and Adamirova, L. (1982). Method of hygienically safe stabilization of polyolefines against thermoxidative and photooxidative degradation. Czechoslovakian Socialist Republic Patent, 221: 403-413. Enqvist, E. (2013). Carbon nanofiller reinforced UHMWPE for orthopaedic applications: optimization of manufacturing parameters (Doctoral dissertation, Luleå tekniska universitet). Luleå University of Technology, Department of Engineering Sciences and Mathematics, Division of Machine Elements, 94. Eun, J.H., Kim, D.H., Jang, I.U., Sung, S.M., Kim, M.S., Choi, B.K., Kang, S.W., Kim, M.S. and Lee, J.S. )2022(. A study on mechanical properties and thermal properties of UHMWPE/MWCNT composite fiber with MWCNT content and draw ratio. Journal of Engineered Fibers and Fabrics, 17:15589250221108484. Fathi, M., Nasrabadi, M.N. and Varshosaz, J. (2017). Characteristics of vitamin E-loaded nanofibres from dextran. International Journal of Food Properties, 20: 2665-2674. Fonseca, A., Kanagaraj, S., Oliveira, M.S. and Simões, J.A. (2011). Enhanced UHMWPE reinforced with MWCNT through mechanical ball-milling. Defect and Diffusion Forum, 312: 1238-1243. Standard, I. (2009). Part 5: Tests for in vitro cytotoxicity. Pages 60-94 in Biological Evaluation Of Medical Devices. Geneve, Switzerland: International Organization for Standardization. Gaziano, J.M. (1994). Natural antioxidants and cardiovascular disease: observational epidemiologic studies and randomized trials. Natural Antioxidants in Human Health and Disease, 59: 735-739 Hassanein, N., Bougherara, H. and Amleh, A. (2020). In-vitro evaluation of the bioactivity and the biocompatibility of a novel coated UHMWPE biomaterial for biomedical applications. Journal of the Mechanical Behavior of Biomedical Materials, 101:103409. Khalil, Y., Hopkinson, N., Kowalski, A. and Fairclough, J.P.A. (2019). Characterisation of UHMWPE polymer powder for laser sintering. Materials, 12: 1-22. Khorasani, M.T., Zaghiyan, M. and Mirzadeh, H. (2005). Ultra high molecular weight polyethylene and polydimethylsiloxane blend as acetabular cup material. Colloids and Surfaces B: Biointerfaces, 41: 169-174. Kurtz, S.M. (2009). UHMWPE Biomaterials Handbook, Ultra High Molecular Weight Polyethylene in Total Joint Replacement and Medical Devices. 2nd edn. Academic Press 544Pp. New York. Melk, L. and Emami, N. (2018). Mechanical and thermal performances of UHMWPE blended vitamin E reinforced carbon nanoparticle composites. Composites Part B: Engineering, 146: 20-27. Muratoglu, O.K., Mark, A., Vittetoe, D.A., Harris, W.H. and Rubash, H.E. (2003). Polyethylene damage in total knees and use of highly crosslinked polyethylene. The Journal of Bone and Joint Surgery, 85: 7-13. Oral, E., Beckos, C.G., Malhi, A.S. and Muratoglu, O.K. (2008). The effects of high dose irradiation on the cross-linking of vitamin E-blended ultrahigh molecular weight polyethylene. Biomaterials, 29: 3557-3560. Oral, E., Greenbaum, E.S., Malhi, A.S., Harris, W.H. and Muratoglu, O.K. (2005) undefined. (2005). Characterization of irradiated blends of α-tocopherol and UHMWPE. Biomaterials, 26: 6657-6663. Oral, E., Wannomae, K.K., Rowell, S.L. and Muratoglu, O.K. (2007). Diffusion of vitamin E in ultra-high molecular weight polyethylene. Biomaterials, 28: 5225-5237. Paladugu, S.R.M. and PS, R. S. (2022). Influence of gamma radiation on wear and oxidation properties of cross-linked UHMWPE components used in total knee arthroplasty-a review. Materials Today: Proceedings, 56: 1097-1102. Pang, W., Ni, Z., Chen, G., Huang, G., Huang, H. and Zhao, Y. (2015). Mechanical and thermal properties of graphene oxide/ultrahigh molecular weight polyethylene nanocomposites. RSC Advances, 5: 63063-63072. Pang, W., Wu, J., Zhang, Q. and Li, G. (2017). Graphene oxide enhanced, radiation cross-linked, vitamin E stabilized oxidation resistant UHMWPE with high hardness and tensile properties. RSC Advances, 7: 55536-55546. Patil, N.A., Njuguna, J. and Kandasubramanian, B. (2020). UHMWPE for biomedical applications: Performance and functionalization. European Polymer Journal, 125:109529. Singh, D.K. and Verma, R.K. (2021). Contemporary development on the performance and functionalization of ultra high molecular weight polyethylene (UHMWPE) for biomedical implants. Nano Life, 11:2130009. Sobajima, A., Okihara, T., Moriyama, S., Nishimura, N., Osawa, T., Miyamae, K., Haniu, H., Aoki, K., Tanaka, M., Usui, Y. and Sako, K.I., Kato, H. and Saito, N. (2020). Multiwall carbon nanotube composites as artificial joint materials. ACS Biomaterials Science and Engineering, 6:7032-7040. Suñer, S. and Emami, N. (2014). Investigation of graphene oxide as reinforcement for orthopaedic applications. Tribology-Materials, Surfaces and Interfaces, 8: 1-6. Wang, R., Zheng, Y., Chen, L., Chen, S., Zhuo, D. and Wu, L.)2020(. Fabrication of high mechanical performance UHMWPE nanocomposites with high‐loading multiwalled carbon nanotubes. Journal of Applied Polymer Science, 137:48667. Wen, X., Li, Z., Yang, C., Yan, K., Wu, G. and Wang, D. (2022). Electron beam irradiation assisted preparation of UHMWPE fiber with 3D cross-linked structure and outstanding creep resistance. Radiation Physics and Chemistry, 199: 1-10. Zavala, J.M.D., Gutiérrez, H.M.L., Segura-Cárdenas, E., Mamidi, N., Morales-Avalos, R., Villela-Castrejón, J. and Elías-Zúñiga, A. )2021(. Manufacture and mechanical properties of knee implants using SWCNTs/UHMWPE composites. Journal of the Mechanical Behavior of Biomedical Materials, 120:104554. Zhu, W., Yan, C., Shi, Y., Wen, S., Liu, J. and Shi, Y. (2015). Investigation into mechanical and microstructural properties of polypropylene manufactured by selective laser sintering in comparison with injection molding counterparts. Materials and Design, 82: 37-45. | ||
|
آمار تعداد مشاهده مقاله: 334 تعداد دریافت فایل اصل مقاله: 101 |
||
