پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 25 |
| تعداد شماره‌ها | 916 |
| تعداد مقالات | 7,528 |
| تعداد مشاهده مقاله | 12,239,051 |
| تعداد دریافت فایل اصل مقاله | 8,656,921 |
اثر زیره سیاه بر فاکتورهای آنتی اکسیدانی و پارامترهای استرس اکسیداتیو در رت‌های مواجه شده با 1 و 2- دی متیل هیدرازین | ||
| زیست شناسی کاربردی | ||
| مقاله 4، دوره 32، شماره 4 - شماره پیاپی 62، اسفند 1398، صفحه 58-75 اصل مقاله (972.04 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22051/jab.2020.4803 | ||
| نویسندگان | ||
| ابوالفضل دادخواه* 1؛ فائزه فاطمی* 2؛ سالومه دینی* 3 | ||
| 1دانشیار بیوشیمی، گروه پزشکی، دانشکده پزشکی، واحد قم، دانشگاه آزاد اسلامی، قم، ایران. | ||
| 2دانشیار بیوشیمی، پژوهشکده مواد و سوخت هسته‌ای، پژوهشگاه علوم و فنون هسته‌ای، تهران، ایران | ||
| 3پژوهشگر، باشگاه پژوهشگران و نخبگان جوان، دانشگاه آزاد اسلامی واحد کرج، کرج، ایران | ||
| چکیده | ||
| در این تحقیق، تاثیرکاربردپودر و اسانس زیره سیاه با دوز 2/0 درصد (w/w)در مهار ایجاد سرطان کولون القاء شده با دی متیل هیدرازین (DMH)بر روی تغییرات شاخص‌های بیوشیمیایی مانند آنزیم‌های کاتالاز(CAT) ،سوپر‌اکسید دیسموتاز(SOD)،گلوتاتیون احیا(GSH)، پر‌اکسیداسیون لیپید(LP)و ظرفیت آنتی اکسیدانی کل پلاسما(FRAP) و همچنین تغییرات پاتولوژیکی مورد بررسی قرار گرفتند .نتایج نشان داد که تزریقDMHباعث افزایش GSH وFRAp و کاهشSOD گردید. در حالیکهتیمار رت‌ها با اسانس و پودر زیره سیاه تاثیری بر روی بهبود پارامترهای بیوشیمیایی نداشته است، نتایج پاتولوژی تاثیر مثبت تیمارها را در روند سرطانزایی نشان دادند. لذا با توجه به نتایج بهدست آمده، فعالیت ضد سرطانی اسانس و پودر زیره سیاه، احتمالا مربوط به اثرات آن در مسیرهای دیگر متابولیکی (غیر از سیستم دفاع آنتی اکسیدانی و استرس اکسیداتیو) می باشد. | ||
| کلیدواژه‌ها | ||
| استرس اکسیداتیو؛ دی متیل هیدرازین؛ زیره سیاه؛ سرطان کولون | ||
| عنوان مقاله [English] | ||
| Effects of Carum carvi L. on Antioxidant status and oxidative stress parameters in rats exposed to 1, 2-dimethyl hydrazine | ||
| نویسندگان [English] | ||
| Aboolfazl Dadchah1؛ Faezeh Fatemi2؛ Saloomeh Dini3 | ||
| 1- Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran | ||
| 2Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran | ||
| 3Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran | ||
| چکیده [English] | ||
| In the current study, the effect of usage of caraway powder and its essential oils at the dose of 0.2% (w/w) were studied on colon cancer prevention induced by dimethyl hydrazine (DMH) through the estimation of biochemical parameters including catalase (CAT) and superoxide dismutase (SOD) enzymes, glutathione (GSH), lipid peroxidation (LP) and ferric reducing ability of plasma (FRAP) as well as histopathological changes. The results showed that the levels of GSH and FRAP were increased and SOD activity was decreased by DMH. Even though caraway powder and its essential oils failed to alter the tested biochemical parameters, histopathological analysis indicated improved effects in carcinogenesis. Therefore, the results demonstrated that the chemopreventive effects of the treatments were due to the other metabolic pathways than oxidative stress/antioxidant systems. | ||
| کلیدواژه‌ها [English] | ||
| Colon cancer, Carum carvi L, Oxidative stress, Dimethyl hydrazine | ||
| مراجع | ||
|
Ansari, R., Mahdavinia, M., Sadjadi, A., Nouraie, M., Kamangar, F., Bishehsari, F., Fakheri, H., Semnani, S., Arshi, S., Zahedi, MJ., Darvish-Moghadam, S., Mansour-Ghanaei, F., Mosavi, A., Malekzadeh, R. (2006). Incidence and age distribution of colorectal cancer in Iran: Results of a population-based cancer registry. Cancer Lett, 18; 240 (1):143-7. Attaran, HR., Fatemi, F., Rasooli, A., Dadkhah, A., Mohammadi Malayeri, MR., Dini, S. (2018). Zataria multiflora essential oil prevent iron oxide nanoparticles-induced. Liver Toxicity in Rat Model. Journal of Medicinal Plants and By-products, 1: 15-24. Attaran, HR., Dini, S., Fatemi, F., Hesaraki, S., Parhizkarie, M., Dadkhaha, A. (2015). Hepatoprotective Evaluation of Iranian Satureja Rechingeri Essential Oils against Oxidative Injuries Induced by Acetaminophen in Wistar Rats. Int. J. Rev. Life. Sci., 5: 204-210. Benzie, I.F.F and Strain, J.J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Anal Biochem, 239: 70-76. Bird, R.P. (1987). Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Let, 37: 147-151. Bobek, P. and Galbavy, S. (2001). Influence of insulin on dimethylhydrazine induced carcinogenesis and antioxidant enzymatic system in rat. Biologia, 56: 287-291. Colussi, C., Fiumicino, S., Giuliani, A., Rosini, S., Musiani, P., Macrí, C., et al. (2001). 1, 2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2 (-/-) mice. Journal of the National Cancer Institute, 93: 1534-40. Dadkhah A, Fooladvand M, Fatemi F, Ashrafi-Helan J. (2014). Chemopreventive effects of caraway powder and oils to suppress 1, 2- dimethylhydrazine-induced colon carcinogenesis. Turk J Biochem, 39(3): 260-269. Dadkhah, A., Fatemi, F., Mohammadi Malayeri, MR., Torabi, F., Sarbazi, M., Dini, S. (2018). Potential protective effect of pretreatment with caraway essential oil in vivo model of iron nanoparticle-induced liver injury. Journal of Medicinal Plants and By-products, 2: 145-152. Dadkhah, A., Khalaj, Gh., Fatemi, F., Dini, S., Naij, S. Fadaee Monfared, M. (2016). Considering the effect of Golpar (Heracleum Persicum) essential oils on the acute hepatotoxcity induced by acetaminophen in Wistar rats. Journal of animal research, 29: 292-306. Dadkhah, A., Fatemi, F., Mohammadi Malayeri, M. R., Karvin Ashtiani, M. H., Mosavi, Z., Naij, S., Dini, S., Ghorbani, N. (2020). The Anti-inflammatory and Antioxidant Effects of Rosa damascena Mill. Essential Oil on the Lung Injury in the CLP Model. Journal of Medicinal Plants, in press. Deeptha, K., Kamaleeswari, M., Sengottuvelan, M., Nalini, N. (2006). Dose dependent inhibitory effect of dietary caraway on 1,2-dimethylhydrazine induced colonic aberrant crypt foci and bacterial enzyme activity in rats. Invest New Drugs, 24: 479-488. Devasena, T., Rajasekaranb, K.N., Menona, V.P. (2002). Bis-1,7-(2-Hydroxyphenyl)-Hepta-1,6-Diene- 3,5-dione (A Curcumin Analog) ameliorates DMH-Induced hepatic oxidative stress during colon carcinogenesis. Pharmacol Res, 46: 39-45. Druckrey, H. (1970). Production of colonic carcinomas by 1,2-dialkylhydrazines and azoxyalkanes. In: Burdette WJ, ed. Carcinoma of the colon and antecedent epithelium. Springfield, IL: Charles C. Thomas 267-279. Eddouks, M., Lemhadri, A., Michel, J.B. (2004). Caraway and caper: potential anti-hyperglycaemic plants in diabetic rats. J Ethnopharmacol, 94: 143-148. Fatemi, F., Dadkhah, A., Akbarzadeh, K., Dini, S., Hatami, S., Rasooli, A. (2015). Hepatoprotective Effects of Deuterium Depleted Water (DDW) Adjuvant with Satureja rechingeri Essential Oils. Electronic Journal of Biology, 11(2):23-32. Fiala, E.S., Sohn, O.S., Hamilton, S.R. (1987). Effects of chronic dietary ethanol on the in vivo and in vitro metabolism of methylazoxymethonol and methylazoxymethanol induced DNA methylation in the rat colon and liver. Cancer Res, 47: 5939-43. Gottesman, M., Fojo, T., Bates, S.E. (2002). Multidrug resistance in cancer: role of ATP dependent transporters. Nat Rev Cancer, 2: 48-58. Harriss, D.J., Atkinson, G., Batterham, A., George, K., Cable, N.T., ReillyT.Haboubi, N., Renehan, A.G. (2009). Colorectal Cancer, Lifestyle, Exercise and Research, Group. "Lifestyle factors and colorectal cancer risk (2): a systematic review and meta-analysis of associations with leisure-time physical activity". Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland 11: 689-701. Jackson, P.E., O'Connor, P.J., Cooper, D.P., Margison, G.P., Povey, A.C. (2003). Associations between tissue-specific DNA alkylation, DNA repair and cell proliferation in the colon and colon tumour yield in mice treated with 1,2-dimethylhydrazine. Carcinogenesis, 24: 527-33. Kamaleeswari, M., Deeptha, K., Sengottuvelan, M., Nalini, N. (2006). Effect of dietary caraway (Carum carvi L.) on aberrant crypt foci development, fecal steroids, and intestinal alkaline phosphatase activities in 1,2-dimethylhydrazine-induced colon carcinogenesis. Toxicol Appl Pharmacol 214: 290-96. Lemhadri, A., Hajji, L., Michel, J.B., Eddouks, M. (2006). Cholesterol and triglycerides lowering activities of caraway fruits in normal and streptozotocin diabetic rats. J Ethnopharmacol, 106: 321-326. Manju, V and Nalini, N. (2005). Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazineinduced colon cancer. Clin Chim Acta, 358: 60-67. Mohammadi Malayeri, MR., Dadkhah, A., Fatemi, F., Dini, S., Torabi, F., Tavajjoh, MM., Rabiei, J. (2016). Chemotherapeutic effect of Berberis integerrima hydroalcoholic extract on colon cancer development in the 1,2-dimethyl hydrazine rat model. Z Naturforsch C J Biosci, 71: 225-32. Rijnkels, J.M and Alink, G.M. (1998). Effects of a vegetables-fruit mixture on liver and colonic 1,2- dimethylhydrazine-metabolizing enzyme activities in rats fed low- or high-fat diets. Cancer Lett, 128: 171-5. Rustgi, A.K. (2007). The genetics of hereditary colon cancer. Genes Dev, 21: 2525-2538. Roshanaei, K., Dadkhah, A., Fatemi, F., Dini S. (2017a). The Protective Effects of Iranian Golpar (Heracleum persicum) Essential Oil in Liver Damages Induced by CCl4 in Wistar Rats. Journal of Medicinal Plants.1:110-122. Roshanaei, K., Dadkhah, A., Fatemi, F., Dini, S. (2017b). Heracleum persicum Essential oil administration in CCL4 treated Rat sustains antioxidant / oxidative stress statue. Advances in Bioresearch. 8: 93-101. Salim, E.I and Fukushima, S. (2003). Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. Nutr Cancer, 45: 195-202. Sengottuvelan, M., Senthilkumar, R., Nalini, N. (2006). Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis. Biochimica et Biophysica Acta, 1760: 1175-1183. Smith, G., Carey, F.A., Beattie, J., Wilkie, M.J.V., Lightfoot, T.J., Coxhead, J., et al. (2002). Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer. PNAS, 99: 9433-9438. Srihari, T., Sengottuvelan, M., Nalini, N. (2008). Dose-dependent effect of oregano (Origanum vulgare L.) on lipid peroxidation and antioxidant status in 1,2-dimethylhydrazine-induced rat colon carcinogenesis. J Pharm Pharmacol, 60: 787-94. Swan, D.K and Ford, B. (1997). Chemoprevention of cancer. Review of the literature. Oncology Nursing Forum, 24: 719-727. Tenesa, A., Dunlop, M.G. (2009). New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat Rev Genet, 10: 353-358. Torabi, F., Dadkhah A., Fatemi, F., Dini, S., Taghizadeh, M., Mohammadi Malayeri, MR. (2015). Prevention and therapy of 1,2-dimethyl hydrazine induced colon carcinogenesis by Ferula assa-foetida hydroalcoholic extract. Turkish Journal of Biochemistry, 40: 390–400.
| ||
|
آمار تعداد مشاهده مقاله: 798 تعداد دریافت فایل اصل مقاله: 342 |
||